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Optimizing Preclinical Imaging. In order to study the nature or diseases, such as those affecting the central nervous system, medical practitioners and scientists often use preclinical models and modalities to assist in their diagnosis, frankly, medical practitioners follow certain guidelines to ensure that the imaging recorded from preclinical models can provide a clear and interpretable data across all fields and assist drug manufacturers a better framework to work on how they can conduct their clinical trials and develop their drugs for a certain disease. Within the development stages, feel free to connect several preclinical imaging specialist with those from other areas so that you can be able to evaluate several model components within the whole structure. You should take into account the particular disease model and the aspects of the different diseases that are being discussed, it may help in examining different aspects of the disease hence translating into a reliable imaging aspect.
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Scaling from rodents up to humans may not be straightforward but the translational aspects of certain parameters-such as metabolites drawn from a magnetic resonance spectroscopy- should be well defined.
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Do not forget to factor in all the components of modeling strategies, these include, the model paradigm, behavior and histopathological components, that should be processed and assessed in respect to the timing of the assays. Whenever possible, it is critical that prior data is availed by the imaging group that shows either a discernible deficit within the modeling paradigm or that the parameters under study can actually be examined by the body conducting the study. So, ensure that you get all the data from the analysis team who are employing any scanner at hand because this will help you understand the methodologies in a very cost effective way, additionally, doing the same experiment with a different scanner will help you know the accurate results of the study. If you are trying to observe any subtle changes when drug is administered to an animal, then be sure to have already used the specific animal model and imaging methodologies together with a couple of tests in order to know the variation within the subject. Discuss openly any exclusion of criteria and when/where/if to replace the subjects in the study within the same context. Looking for high quality throughout, then do not be worries, because these terms can co-exist, but you have to do it in a careful manner where you only extract relevant information while understanding the capability of retention of the imaging. Of course, do not forget to discuss with experts the methodologies possible for the study to retain the expectations for the study and make it easier to interpret the data coming from imaging studies.